DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 30 Yrs Exp. in the feld of Organic Chemistry. Serving chemists around the world. Helping them with websites on Chemistry.Millions of hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution
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Showing posts with label ORGANIC REACTIONS. Show all posts
Showing posts with label ORGANIC REACTIONS. Show all posts

Wednesday 31 July 2013

The Sulfonamide Motif as a Synthetic Tool




Sulfonamides are well known motifs in medicinal chemistry, forming a large family of antibacterial agents as well as being found in numerous other drugs.  The chemistry of this functional group, however, is less well documented.  This review seeks to bring together the various applications and advantages of this motif in organic synthesis, which includes the sulfonamide as an activating group, protecting group, leaving group and as a molecular scaffold.
http://www.ingentaconnect.com/content/stl/jcr/2010/00000034/00000010/art00001


 The Sulfonamide Motif as a Synthetic Tool
Jonathan Wilden obtained his PhD from the University of Southampton in 2001 having worked on the total synthesis of the marine natural product pseudopterosin with Professor David Harrowven.  He then moved to the University of Sussex, Brighton, UK where his interest in sulfonamide chemistry began, working with Professor Steve Caddick.  In 2004 he was appointed lecturer at University College London where his research interests include the synthesis of medicinally important compounds and exploitation of the sulfonamide group in organic synthesis.

Monday 29 July 2013

Nickel-Catalyzed Suzuki–Miyaura Couplings in Green Solvents

Figure

Nickel-Catalyzed Suzuki–Miyaura Couplings in Green Solvents

Publication Date (Web): July 23, 2013 (Letter)
DOI: 10.1021/ol401727y

The nickel-catalyzed Suzuki–Miyaura coupling of aryl halides and phenol-derived substrates with aryl boronic acids using green solvents, such as 2-Me-THF and tert-amyl alcohol, is reported. This methodology employs the commercially available and air-stable precatalyst, NiCl2(PCy3)2, and gives biaryl products in synthetically useful to excellent yields. Using this protocol, bis(heterocyclic) frameworks can be assembled efficiently.

Friday 26 July 2013

One-Pot Approach to α,β-Unsaturated Carboxylic Acids

thumbnail image: One-Pot Approach to α,β-Unsaturated Carboxylic Acids

 

One-Pot Approach to α,β-Unsaturated Carboxylic Acids

Carboxylation of alkynes with carbon dioxide in a one-pot approach could become a practical route to unsaturated carboxylic acids
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Tuesday 23 July 2013

Nano-Technoloogy Makes Medicine Greener


The ultra small nanoreactors have walls made of lipids. During their fusion events volumes of one billionth of a billionth of a liter were transferred between nanoreactors allowing their cargos to mix and react chemically. We typically carried out a million of individual chemical reactions per cm2 in not more than a few minutes. (Credit: Image courtesy of University of Copenhagen)http://www.sciencedaily.com/releases/2011/11/111103132357.htm
 Researchers at the University of Copenhagen are behind the development of a new method that will make it possible to develop drugs faster and greener. Their work promises cheaper medicine for consumers.
Over the last 5 years the Bionano Group at the Nano-Science Center and the Department of Neuroscience and Pharmacology at the University of Copenhagen has been working hard to characterise and test how molecules react, combine together and form larger molecules, which can be used in the development of new medicine.http://www.sciencedaily.com/releases/2011/11/111103132357.htm



Wednesday 17 July 2013

Building nanographene by organic synthesis



Direct C-H coupling of pyrene makes nanographenes with defined shape and edge structures

Direct C-H coupling of pyrene makes nanographenes with defined shape and edge structures

Japanese scientists are making tiny fragments of graphene using direct
cross-coupling of C-H bonds to determine what effect size and edge geometry
have on the properties of carbon materials. By bolting together aromatic hydrocarbons, they can
build nanographene fragments with defined shapes in an attempt to relate geometry to performance.
Speaking at the RSC’s seventh International Symposium on Advancing the Chemical Sciences in Edinburgh, UK, Kenichiro Itami from Nagoya University explained .............read all at

Tuesday 16 July 2013

A new labdane diterpene from Rauvolfia tetraphylla Linn. (Apocynaceae)

A new labdane diterpene from Rauvolfia tetraphylla Linn. (Apocynaceae)
A new labdane diterpene from Rauvolfia tetraphylla Linn. (Apocynaceae)

Rauvolfia tetraphylla Linn. (syn. R. canescens L., family: Apocynaceae) holds an important position in the Indian traditional system of medicine, and has other immense applications. This particular plant is regarded as a rich source of a wide variety of important alkaloid constituents such as reserpine, reserpiline, raujemidine, isoreserpiline, deserpidine, aricine, ajmaline, ajmalicine, yohimbines, serpentine, sarpagine, vellosimine and tetrphylline. However, there is no report on the terpenoid constituent from this plant, and we report the isolation from the air-dried stems and branches of R. tetraphylla and structural elucidation of a new labdane diterpene, 3-hydroxy-labda-8(17),13(14)-dien-12(15)-olide (1; Fig. 1) bearing  an unusual -lactone moiety.
Structure of labdane diterpene
Fig. 1 Structure of labdane diterpene
Goutam Brahmachari*, Lalan Ch. Mandal, Dilip Gorai, Avijit Mondal, Sajal Sarkar and Sasadhar Majhi
Doi: 10.3184/174751911X13220462651507

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Novel uses of nanoparticle catalytic systems

Novel uses of nanoparticle catalytic systems
Novel uses of nanoparticle catalytic systems

Easily prepared and recoverable nanoparticles with a diameter of 10–40 nm, with a high surface area and stability may provide a catalytic system or the support for a catalyst.

Friday 12 July 2013

Turning carbon dioxide into something useful -Carbon dioxide reduced to formate by iridium pincer catalyst







http://www.rsc.org/chemistryworld/2013/07/iridium-catalyst-carbon-dioxide-reduction-formate

New research shows that a water-soluble catalyst developed by scientists in the US can electrocatalytically transform carbon dioxide into a useful chemical feedstock.
The global demand for fuel is rising, as are carbon dioxide levels in the atmosphere. Recent studies have attempted to address the global carbon imbalance by exploring ways to recycle carbon dioxide into liquid fuels. Formate, the anion of formic acid, is an intermediate of carbon dioxide reduction and can be used as a fuel in formic acid fuel cells. However, the selective production of formate, without using organic solvents, is challenging. Water, being inexpensive and environmentally-friendly, is obviously preferred over organic solvents as a reaction medium. On the other hand, the reduction of carbon dioxide in water is complicated by the reduction of water to hydrogen being a more kinetically favourable process.
 http://www.rsc.org/chemistryworld/2013/07/iridium-catalyst-carbon-dioxide-reduction-formate


Thursday 27 June 2013

A molecular database for developing organic solar cells


molecular_space_logo




Harvard researchers have released a massive database of more than 2 million molecules that might be useful in the construction of solar cells that rely on organic compounds for construction of organic solar cells for the production of renewable energy. Developed as part of the Materials Genome Initiative launched by the White House’s Office of … more…

http://www.kurzweilai.net/a-molecular-database-for-developing-organic-solar-cells?utm_source=KurzweilAI+Daily+Newsletter&utm_campaign=4fc1bf53a4-UA-946742-1&utm_medium=email&utm_term=0_6de721fb33-4fc1bf53a4-282116853





Tuesday 11 June 2013

Bruce Roth Awarded 2013 Perkin Medal


Bruce Roth
Roth
Credit: Genentech

Bruce Roth Awarded 2013 Perkin Medal

Honors: Chemist was the first to synthesize the cholesterol-lowering drug atorvastatin, also known as Lipitor
The Society of Chemical Industry (SCI) has selected Bruce D. Roth, vice president of discovery chemistry at Genentech, as the winner of the 2013 Perkin Medal. The annual award is recognized as the highest honor given for outstanding work in applied chemistry in the U.S.
http://cen.acs.org/articles/91/web/2013/06/Bruce-Roth-Awarded-2013-Perkin.html




A Molecule Of Many Colors-With rigid wings and a flexible core, a new compound can switch between two shapes and glow one of three colors.


Structure of a flexible molecule in its flat and bent shapes
 
Flexible And Fluorescent
A molecule combining rigid anthraceneimide wings and a flexible cyclooctatetraene core switches between a flat and a bent V shape. The R groups are either hydrogens or n-butyl groups.
Credit: J. Am. Chem. Soc.

A Molecule Of Many Colors

Organic Chemistry: With rigid wings and a flexible core, a new compound can switch between two shapes and glow one of three colors.

A new, flexible, multi-ring organic compound fluoresces red, green, or blue depending on its environment (J. Am. Chem. Soc. 2013, DOI: 10.1021/ja404198h). The molecule’s combination of rigid wings and a flexible center could serve as a general design strategy for molecular sensors, the researchers say.
The molecule, developed by a team of researchers, including Shohei Saito, Stephan Irle, and Shigehiro Yamaguchi of Nagoya University in Japan, has two rigid anthraceneimide wings on opposite sides of a floppy cyclooctatetraene core

read all at
http://cen.acs.org/articles/91/web/2013/06/Molecule-Colors.html

Monday 10 June 2013

ORGANIC CHEMISTRY REACTIONS, website by DR ANTHONY CRASTO

 

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https://sites.google.com/site/anthonycrastoreactions/home

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