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Showing posts with label Continuous-Flow Synthesis. Show all posts
Showing posts with label Continuous-Flow Synthesis. Show all posts

Tuesday 28 October 2014

A Fully Automated Continuous Flow Synthesis of 4,5-Disbustituted Oxaxoles










A Fully Automated Continuous Flow Synthesis of 4,5-Disbustituted Oxaxoles 
M. Baumann, I.R. Baxendale, S.V. Ley, C.D. Smith and G.K. Tranmer, Org. Lett. 2006, 8, 5231-5234.
 http://pubs.acs.org/doi/abs/10.1021/ol061975c

 A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configured to provide the maximum flexibility for screening of reaction parameters that incorporate on-chip mixing and columns of solid supported reagents to expedite the chemical syntheses.


Sunday 5 February 2012

800 photoreactors should suffice to cover the global requirement for Artemisinin

800 photoreactors should suffice to cover the global requirement for Artemisinin
After just four and a half minutes a solution flows out of the tube, in which 40 percent of the artemisinic acid has become artemisinin.
READ MORE AT
François Lévesque and Peter H. Seeberger, Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin, Angewandte Chemie International Edition, 16 January 2012; DOI: 10.1002/anie.201107446