DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution
n

Saturday, 29 November 2014

A route to convert CO2: synthesis of 3,4,5-trisubstituted oxazolones



Green Chem., 2015, Advance Article
DOI: 10.1039/C4GC02033B, Paper
Jiayin Hu, Jun Ma, Zhaofu Zhang, Qinggong Zhu, Huacong Zhou, Wenjing Lu, Buxing Han
CO2 can react with various propargylic amines to form 3,4,5-trisubstituted oxazolones catalyzed by the active, selective and stable ionic liquids.


Production of value-added chemicals using carbon dioxide (CO2) as a feedstock is favorable to the sustainable development of the chemical industry. In this work, we have discovered for the first time that CO2 can react with propargylic amines to produce 3,4,5-trisubstituted oxazolones, a class of very useful chemicals. It was found that the ionic liquid (IL) 1-butyl-3-methylimidazolium acetate ([Bmim][OAc]) can catalyze the reactions efficiently at atmospheric pressure under metal-free conditions. It was also found that [Bmim][OAc] and IL 1-butyl-3-methylimidazolium bis((trifluoromethyl)sulfonyl)imide ([Bmim][Tf2N]) have an excellent synergistic effect for promoting the reactions. The [Bmim][OAc]/[Bmim][Tf2N] catalytic system can be reused at least five times without loss in catalytic activity and selectivity. The reaction mechanism was proposed on the basis of density functional theory (DFT) calculation and the experimental results.

Friday, 14 November 2014

New Pentafluorosulfanyls



New Pentafluorosulfanyls







Transformation of an existing heterocyclic sulfur functionality to prepare SF5-substituted heterocycles
Read more

 http://www.chemistryviews.org/details/ezine/6924381/New_Pentafluorosulfanyls.html

Formal Total Synthesis of (–)-Taxol



Formal Total Synthesis of (–)-Taxol







Pd-catalyzed eight-membered carbocyclic ring formation
Read more

Telling Solvents Apart the Easy Way



Telling Solvents Apart the Easy Way







Help could be soon on hand for the horrible moment of thinking "What solvent did I just add to that reaction?"
Read more

 http://www.chemistryviews.org/details/ezine/6830971/Telling_Solvents_Apart_the_Easy_Way.html

Catalytic Nitration of Anilines



Catalytic Nitration of Anilines






A copper-catalyzed mild nitration of protected anilines
Read more

 http://www.chemistryviews.org/details/ezine/6712381/Catalytic_Nitration_of_Anilines.html

Solid Approach to Product Extraction









An effective solid-extraction method to simplify the workup of organic reactions
Read more

 http://www.chemistryviews.org/details/news/6835901/Solid_Approach_to_Product_Extraction.html