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Sunday 2 September 2012

SYNTHESIS OF INDOLES

http://onlinelibrary.wiley.com/doi/10.1002/anie.201203657/abstract

Synthesis of Indoles 

Synthesis of Indoles through Highly Efficient Cascade Reactions of Sulfur Ylides and N-(ortho-Chloromethyl)aryl Amides 
Qing-Qing Yang, ET AL
DOI: 10.1002/anie.201203657
Thumbnail image of graphical abstract


A simple procedure carried out under mild conditions allows the direct and efficient synthesis of structurally diverse indoles. This approach involves a cascade reaction of sulfur ylides and N-(ortho-chloromethyl)aryl amides (see scheme).

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